Pioneering GRP research for human health
Founded by the team that discovered GRP, we provide the only GRP ELISA validated in peer-reviewed articles and a portfolio of in-house developed GRP reagents.
20
Publications
Since 2008
GRP Research
Unique
Carboxylation-state specific GRP antibodies
Why choose GenoGla?
Founded by the team that discovered GRP, we provide the only GRP ELISA validated in peer-reviewed articles (Biochem Med 2026, ATVB 2018) and reagents we developed in-house.
Research excellence
Over fifteen years of GRP research, with peer-reviewed publications across cardiovascular, kidney, joint and inflammation biology.
Expert services
Total GRP ELISA analysis and custom analysis services, backed by our expertise in GRP biology.
Validated products
Research-grade antibodies and proteins, supplied with documented specifications and validation.
Research applications
Our GRP reagents and analysis service support research across multiple areas of human health where calcification and inflammation play key roles.
Cardiovascular
Vascular calcification, atherosclerosis, valve disease
GRP is a key regulator of vascular calcification and contributes to the maintenance of vascular health.
Nephrology
CKD-MBD, cardiovascular risk, calciphylaxis, dialysis complications
Understanding mineral metabolism dysfunction, vascular calcification and cardiovascular risk in kidney disease patients.
Osteoarthritis
Cartilage calcification, joint inflammation and ECM integrity
Investigating the role of GRP in regulating inflammation, pathological mineralization, and cartilage protection.
Oncology
Tumor microenvironment, extracellular matrix remodeling
Investigating the emerging role of GRP in cancer biology, tissue remodeling and tumor progression.
Featured research
Pioneering research establishing GRP as a key regulator of pathological calcification and inflammation, and a promising biomarker in cardiovascular and kidney disease.
Fundamental research
Arteriosclerosis, Thrombosis, and Vascular Biology • 2015
Gla-Rich Protein Acts as a Calcification Inhibitor in the Human Cardiovascular System
Viegas CSB et al.
Demonstrated that GRP inhibits vascular and valvular calcification by preventing osteochondrogenic differentiation and modulating extracellular vesicle-mediated mineralization.
View publicationArteriosclerosis, Thrombosis, and Vascular Biology • 2018
Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification
Viegas CSB et al.
Identified GRP as a component of circulating calciprotein particles and extracellular vesicles involved in vascular calcification in chronic kidney disease.
View publicationCellular and Molecular Life Sciences • 2016
Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis
Cavaco S et al.
Demonstrated that GRP participates in the cross-talk between calcification and inflammation in osteoarthritis, linking the two processes in joint tissue.
View publicationClinical research
Journal of Clinical Medicine • 2020
Gla-Rich Protein (GRP) as an Early and Novel Marker of Vascular Calcification and Kidney Dysfunction in Diabetic Patients with CKD: A Pilot Cross-Sectional Study
Silva AP et al.
First clinical study of circulating GRP in diabetic CKD patients, highlighting low circulating GRP as a potential early marker of vascular calcification and kidney dysfunction.
View publicationJournal of Clinical Medicine • 2024
Gla-Rich Protein Is Associated with Vascular Calcification, Inflammation, and Mineral Markers in Peritoneal Dialysis Patients
Marreiros C et al.
Demonstrated the clinical relevance of circulating GRP in peritoneal dialysis patients through its association with vascular calcification, inflammation and mineral metabolism markers.
View publication