Selected References


  1. Gla-rich Protein (GRP), A New Vitamin K-dependent Protein Identified from Sturgeon Cartilage and Highly Conserved in Vertebrates. Viegas CSB, Simes DC, Laizé V, Williamson MK, Price PA, Cancela ML. J Biol Chem. 283(52):36655-64. (2008)

  2. Gla-rich protein (GRP) is a novel vitamin K dependent protein present in serum and accumulated at sites of pathological calcifications. Viegas CS, Cavaco S, Neves PL, Ferreira A, João A, Williamson MK, Price PA, Cancela ML., Simes DC, Am J Pathol, 175(6):2288-98. Epub 2009 Nov 5. doi: 10.2353/ajpath.2009.090474 (2009)

  3. Expression of Gla-rich protein (GRP) in newly developed cartilage-derived cell cultures from sturgeon (Acipenser naccarii) CSB Viegas, N Conceição, C Fazenda, DC Simes, ML Cancela, J. Appl. Ichthyol. 26: 214–218 (2010)

  4. Gla‐rich protein is a potential new vitamin K target in cancer: Evidences for a direct GRP‐mineral interaction, CSB Viegas, M Herfs, MS Rafael, JL Enriquez, A Teixeira, I Luís, CMR van ‘t Hoofd, A João, VL Maria, S Cavaco, A Ferreira, M Serra, E Theuwissen, C Vermeer, DC Simes. BioMed Research International, vol. 2014, Article ID 340216, 1-14. doi:10.1155/2014/340216 (2014)

  5. Insights into the association of Gla-rich protein (GRP) and osteoarthritis: novel splice variants and g-carboxylation status. MS Rafael, S Cavaco, CSB Viegas, S Santos, A Ramos, B Willems, M Herfs, E Theuwissen, C Vermeer, DC Simes, Mol. Nutr. Food Res., 58(8):1636-46. DOI:10.1002/mnfr.201300941 (2014)

  6. Gla-rich protein acts as a calcification inhibitor in the human cardiovascular system. Viegas CSB, Rafael SM, Enriquez JL, Teixeira A, Vitorino R, Luís IM, Rubén MC, Santos S, Cavaco S, Neves J, Willems B, Vermeer C, Simes DC, Arterioscler. Thromb. Vasc. Biol.; 35(2):399-408. DOI: 10.1161/ATVBAHA.114.304823 (2015)

  7. Gla-rich protein is involved in the cross talk between calcification and inflammation in osteoarthritis. Cavaco S, Viegas CS, Rafael MS, Ramos A, Magalhães J, Blanco FJ, Vermeer C, Simes DC. Cell Mol Life Sci. Mar;73(5):1051-65 DOI: 10.1007/s00018-015-2033-9 (2016)

  8. New Perspectives for the Nutritional Value of Vitamin K in Human Health. Viegas CS and Simes DC, J Nutr Disorders Ther 6:3 (2016),

  9. Gla-rich Protein (GRP): A New Player in the Burden of Vascular Calcification. Viegas CS and Simes DC, J Cardiovasc Dis Diagn , 4: 245 DOI: 10.4172/2329-9517.1000245 (2016)

  10. Dysregulated fetuin–mineral complexes are linked to vascular calcification in chronic kidney disease: The role of Gla-rich protein. Carla S. B. Viegas, Anjos L. Macedo, Rute Morais, Lúcia Santos, António P. A. Matos, Ana P. Silva, Pedro Neves, Dina C. Simes Ultrastructural Pathology, 41:1, 78-80, DOI: 10.1080/01913123.2016.1269490 (2017)

  11. Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases. Viegas CSB, Costa RM, Santos L, Videira PA, Silva Z, Araújo N, Simes DC PLoS ONE 12(5): e0177829. (2017)

  12. Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: a role for GRP (Gla-rich protein). Viegas CSB, Santos L, Macedo AL, Matos AP, Silva AP, Neves PL, Staes A, Gevaert K, Morais R, Vermeer C, Schurgers L, Simes DC. Arterioscler Thromb Vasc Biol. 38(3):575-587. doi: 10.1161/ATVBAHA.117.310578. Epub 2018 Jan 4 (2018)

  13. Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signaling. Brecht A. Willems, Malgorzata Furmanik, Marjolein M.J. Caron, Martijn L.L. Chatrou, Dennis HM Kusters, Tim J.M. Welting, Michael Stock, Marta S. Rafael, Carla S.B. Viegas, Dina C. Simes, Cees Vermeer, Chris P.M. Reutelingsperger, Leon J. Schurgers. (2018) Scientific Reports 8:4961 | DOI:10.1038/s41598-018-23353-y (2018)
  14. Gla-Rich Protein as a novel marker for calcifications in diabetic patients with CKD. Ana Paula Silva, Carla Viegas, Dina Simes, Filipa Mendes, Nelson Tavares, Fatima Rato, Nelio Santos, Pedro Neves. Nephrology Dialysis Transplantation. 33 (Suppl_1): i493, (2018)




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