Selected References
- 1. Gla Rich Protein is associated with vascular calcification, inflammation and mineral markers in Peritoneal Dialysis Patients. Marreiros C, Viegas C, Silva AP, Faísca M, Schurgers L, Simes D. J Clin Med, 13(23):7429. doi: 10.3390/jcm13237429. (2024)
- Gla rich protein (GRP) mediates VSMCs osteogenic differentiation, extracellular vesicles (EVs) calcification propensity and immunomodulatory properties. Viegas C, Carreira J, Maia T, Macedo AL, Matos AP, Neves J, Simes D. Int J Mol Sci, 25(22):12406. doi: 10.3390/ijms252212406. (2024)
- Nanoencapsulation of Gla-Rich Protein (GRP) as a Novel Approach to Target Inflammation. Viegas CSB, Araújo N, Carreira J, Pontes JF, Macedo AL, Vinhas M, Moreira AS, Faria TQ, Grenha A, de Matos AA, Schurgers L, Vermeer C, Simes DC. Int J Mol Sci. 23(9):4813. doi: 10.3390/ijms23094813. (2022)
- Gla-Rich Protein, Magnesium and Phosphate Associate with Mitral and Aortic Valves Calcification in Diabetic Patients with Moderate CKD. Silva AP, Viegas CSB, Guilherme P, Tavares N, Dias C, Rato F, Santos N, Faísca M, de Almeida E, Neves PL, Simes DC. Diagnostics. 12(2):496. doi: 10.3390/diagnostics12020496 (2022)
- Gla-Rich Protein (GRP) as an Early and Novel Marker of Vascular Calcification and Kidney Dysfunction in Diabetic Patients with CKD: A Pilot Cross-Sectional Study. Silva AP, Viegas CS, Mendes F, Macedo A, Guilherme P, Tavares N, Dias C, Rato F, Santos N, Faísca M, de Almeida E, Neves PL, Simes DC. J Clin Med. 9(3). pii: E635. (2020)
- Vitamin K as a Diet Supplement with Impact in Human Health: Current Evidence in Age-Related Diseases. Simes DC, Viegas CSB, Araújo N, Marreiros C. Nutrients 2020, 12(1), 138; doi: 10.3390/nu12010138. (2020)
- Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. Simes DC, Viegas CSB, Araújo N, Marreiros C. Int J Mol Sci. 20(17). pii: E4150. doi: 10.3390/ijms20174150. (2019)
- The interplay between mineral metabolism, vascular calcification and inflammation in Chronic Kidney Disease (CKD): challenging old concepts with new facts. Viegas C, Araújo N, Marreiros C, Simes D. Aging (Albany NY). 11(12):4274-4299. doi: 10.18632/aging.102046. (2019)
- Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signaling. Brecht A. Willems, Malgorzata Furmanik, Marjolein M.J. Caron, Martijn L.L. Chatrou, Dennis HM Kusters, Tim J.M. Welting, Michael Stock, Marta S. Rafael, Carla S.B. Viegas, Dina C. Simes, Cees Vermeer, Chris P.M. Reutelingsperger, Leon J. Schurgers. (2018) Scientific Reports 8:4961 | DOI:10.1038/s41598-018-23353-y (2018)
- Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: a role for GRP (Gla-rich protein). Viegas CSB, Santos L, Macedo AL, Matos AP, Silva AP, Neves PL, Staes A, Gevaert K, Morais R, Vermeer C, Schurgers L, Simes DC. Arterioscler Thromb Vasc Biol. 38(3):575-587. doi: 10.1161/ATVBAHA.117.310578. (2018)
- Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases. Viegas CSB, Costa RM, Santos L, Videira PA, Silva Z, Araújo N, Simes DC PLoS ONE 12(5): e0177829. https://doi.org/10.1371/journal.pone.0177829 (2017)
- Dysregulated fetuin–mineral complexes are linked to vascular calcification in chronic kidney disease: The role of Gla-rich protein. Carla S. B. Viegas, Anjos L. Macedo, Rute Morais, Lúcia Santos, António P. A. Matos, Ana P. Silva, Pedro Neves, Dina C. Simes Ultrastructural Pathology, 41:1, 78-80, DOI: 10.1080/01913123.2016.1269490 (2017)
- Gla-rich protein is involved in the cross talk between calcification and inflammation in osteoarthritis. Cavaco S, Viegas CS, Rafael MS, Ramos A, Magalhães J, Blanco FJ, Vermeer C, Simes DC. Cell Mol Life Sci. Mar;73(5):1051-65 DOI: 10.1007/s00018-015-2033-9 (2016)
- Gla-rich protein acts as a calcification inhibitor in the human cardiovascular system. Viegas CSB, Rafael SM, Enriquez JL, Teixeira A, Vitorino R, Luís IM, Rubén MC, Santos S, Cavaco S, Neves J, Willems B, Vermeer C, Simes DC, Arterioscler. Thromb. Vasc. Biol.; 35(2):399-408. DOI: 10.1161/ATVBAHA.114.304823 (2015)
- Insights into the association of Gla-rich protein (GRP) and osteoarthritis: novel splice variants and g-carboxylation status. MS Rafael, S Cavaco, CSB Viegas, S Santos, A Ramos, B Willems, M Herfs, E Theuwissen, C Vermeer, DC Simes, Mol. Nutr. Food Res., 58(8):1636-46. DOI:10.1002/mnfr.201300941 (2014)
- Gla‐rich protein is a potential new vitamin K target in cancer: Evidences for a direct GRP‐mineral interaction, CSB Viegas, M Herfs, MS Rafael, JL Enriquez, A Teixeira, I Luís, CMR van ‘t Hoofd, A João, VL Maria, S Cavaco, A Ferreira, M Serra, E Theuwissen, C Vermeer, DC Simes. BioMed Research International, vol. 2014, Article ID 340216, 1-14. doi:10.1155/2014/340216 (2014)
- Gla-rich protein (GRP) is a novel vitamin K dependent protein present in serum and accumulated at sites of pathological calcifications. Viegas CS, Cavaco S, Neves PL, Ferreira A, João A, Williamson MK, Price PA, Cancela ML., Simes DC, Am J Pathol, 175(6):2288-98. Epub 2009 Nov 5. doi: 10.2353/ajpath.2009.090474 (2009)
- Gla-rich Protein (GRP), A New Vitamin K-dependent Protein Identified from Sturgeon Cartilage and Highly Conserved in Vertebrates. Viegas CSB, Simes DC, Laizé V, Williamson MK, Price PA, Cancela ML. J Biol Chem. 283(52):36655-64. (2008)
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