R&D
 GenoGla main area of interest lies within the area of Biomedical Research and Technology around vitamin K dependent proteins, specifically GRP.
Our team brings extensive experience in the research of vitamin K and vitamin K–dependent proteins (VKDPs), including the well-known mineralization-associated osteocalcin and matrix Gla protein (MGP). We hold unique expertise in the most recently identified VKDP, Gla-rich protein (GRP), a promising new biomarker and potential therapeutic agent for disorders associated with pathological calcification and inflammation of soft tissues. These conditions include cardiovascular diseases involving vascular calcification and atherosclerosis, tumor calcification, osteoarthritis, and skin disorders such as dermatomyositis, pseudoxanthoma elasticum (PXE), and scleroderma.
Ongoing research in collaboration with CCMAR- Functional Biochemistry and Proteomics and other institutions
| Studies for the establishment of GRP as a biomarker for vascular calcification (in collaboration with (i) Nephrology Department; (ii) Cardiovascular Department, Faro Hospital, Portugal (iii). |
Studies to unveil the function of GRP associated with several skin calcification related pathologies (PXE, scleroderma, dermatomyositis) (in collaboration with Department of Dermatology, Lisbon Central Hospital, Lisbon, Portugal). |
The application of proteomics to human articular cartilage: A new approach for the identification of osteoarthritis biomarkers (in collaboration with Faro Hospital, Orthopedics and Trauma department, Portugal) |
| Characterization of Gla-rich Protein (GRP) function in normal and pathological mineralization processes. |
Biochemical characterization of circulating GRP. |
Exploring the therapeutic potential of GRP through novel nanoformulations for targeted delivery and enhanced bioactivity. |
We are open and searching for other main research /collaboration partners that could give a positive and strong input to our research interests.
Patents
U. S. Patent 61/136.315 filled in 27 August 2008
PCT/PT2009000046, 27 August 2009, pending
|
